P2Y12 Receptor Platelet Disorder in Greater Swiss Mountain Dogs

Print this out and take to your vet - P2Y12 Info and Form

A platelet disorder has recently been identified in Greater Swiss Mountain Dogs
at the functional and molecular level [1].

The first dog documented to have the disorder bled excessively following a routine spay. 
Platelets are small, circulating cytoplasmic fragments that are the first line of defense in stopping the flow of blood from injured blood vessels.
An important aspect of platelet function is their ability to stick to each other and plug holes in damaged vessels until blood clotting and tissue repair can occur.

The platelets in affected Greater Swiss Mountain dogs are unable to respond properly to a specific platelet activating agent because of a dysfunctional or missing receptor.
Therefore, these dogs are at increased risk for spontaneous hemorrhage and
they are also at high risk for excessive hemorrhage as a result of injury or surgery.

Post operative hemorrhage may be life threatening.
The types of spontaneous bleeding that may occur include excessive gingival bleeding
during tooth eruption, nose bleeds, and superficial skin bleeds.

By using DNA testing, affected and carrier animals can be identified by submitting a blood sample through the mail. Carrier detection is vital in controlling spread of inherited defects and DNA testing is the only reliable method of detecting these animals.
The sample required for testing for the platelet disorder in Greater Swiss Mountain dogs

is a 2 ml EDTA tube (purple top) containing at least 1 ml of whole blood.
Care should be taken to not cross contaminate samples during collection,
particularly if more than one dog is collected at the same time.
Samples should be labeled clearly so that there is no confusion regarding sample identification. Samples should be shipped to the address below. Take care to make sure tubes are protected well to prevent breakage during shipping. The fee for testing is $100 per sample.

1. Boudreaux MK, Martin M. P2Y12 receptor gene mutation associated with postoperative
hemorrhage in a Greater Swiss Mountain dog. Vet Clin Pathol 40(2):202-6, 2011.
Make checks payable to: Auburn University, Department of Pathobiology.